Furan and Lactam Jadomycin Biosynthetic Congeners Isolated from Streptomyces venezuelae ISP5230 Cultured with Nε-Trifluoroacetyl-l-lysine

Journal of Natural Products
2017.0

Abstract

Angucycline antibiotics are composed of a classical four-ring angularly linked polyaromatic backbone. Differential cyclization chemistry of the A- and B-rings in jadomycin biosynthesis led to the discovery of two new furan analogues, while oxidation led to a ring-opened form of the jadomycin N

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Furan and Lactam Jadomycin Biosynthetic Congeners Isolated from <i>Streptomyces venezuelae</i> ISP5230 Cultured with <i>N</i><sub>ε</sub>-Trifluoroacetyl-<scp>l</scp>-lysine
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