<jats:title>Abstract</jats:title><jats:p>Jadomycins are unique angucycline polyketides produced by <jats:italic>Streptomyces venezuelae</jats:italic> soil bacteria under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the jadomycin class of natural compounds in terms of biological activity, biosynthesis, and synthesis. This review outlines recent developments in the study of the synthesis and biosynthesis of jadomycins.