During our screening program for secondary metabolites, we have isolated two new compounds named aranochlor A (1) and aranochlor B (2), as minor components from the fermented broth of the fungal strain Pseudoarachniotus roseus (HIL Y-30499). Earlier, we had reported the isolation and characterization of aranorosin, aranorosinol A and aranorosinol B from the same fungal strain. Herein, we report the isolation, structure elucidation and biological properties of aranochlor A (1) and aranochlor B (2), which are structurally related to aranorosin.