14‘-Hydroxymytoxin B and 16-Hydroxyroridin E, Two New Cytotoxic Trichothecenes fromMyrothecium roridum

Journal of Natural Products
2002.0

Abstract

Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.

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