Antimalarial Activity of Macrocyclic Trichothecenes Isolated from the Fungus Myrothecium verrucaria

Journal of Natural Products
1999.0

Abstract

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.

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