Among compounds previously isolated from the fruit of Piper guineense are piperine and related amides, lignans, guineensine and its lower homologue. We have recently indicated that the components of the fruits of P. guineense vary with plant location. We have now examined the extracts of the fruits, stems and roots of P. guineense collected near Buea in Cameroon and isolated two new amides, 4,5-dihydro-2'-methoxy piperine from fruits and 2'-methoxy-piperine from stems, as well as 4,5-dihydro-piperine from roots whose IR, UV, NMR and MS were in agreement with published data. Though these results confirm that there is variation in fruit contents with plant location, other results demonstrating the presence of 2'-methoxypiperine in Nigerian and Ghanain varieties indicate that the variation may be quantitative rather than qualitative. The present isolation of piperine amides with a tetrasubstituted benzene ring from P. guineense complements the earlier isolation of aschatin, a lignan with a tetrasubstituted benzene ring from the same source.