Extraction of the fruits of P. guineense with petroleum has yielded the isobutylamides of 13- (3.4-methylenedioxyphenyl) 24.1 2-tridecatrienoic, 1 3- (3.4-methylenedioxyphenyl) undeca-2.4.12-trienoic, eicosa-2,4-dienoic. octadeca-2.4-dienoic, and hexadeca-2.4-dienoic acids, as well as the known amides piperine, trichostachine, and piperlonguminine, and a mixture of unidentified sterols. PIPER GUINEENSE (Piperaceae) is a climber which is semicultivated in the forest regions of Nigeria. It is commonly used as an ingredient in local medicinal preparations and as a spice in foods. The genus Piper has been widely investigated chemically and shown to contain piperine (I) type amides. The fruits of Piper guineense have been shown to exhibit variation in their chemical composition dependent on geographical location, and to contain piperine and its isomers as well as a number of lignans. We have examined extracts of the fruits of P. guineense collected in the Western parts of Nigeria and found sesamin and three known piperine-type amides, as well as five new amides.