<jats:p>Two specimens of a marine sponge Psammopemma sp. collected from Prydz Bay, Antarctica, have been found to contain three new brominated 4-hydroxyindole alkaloids: psammopemmin A (4), -B (5) and -C (6). These novel secondary metabolites, which also incorporate a unique 2-bromopyrimidine moiety, have been assigned structures on the basis of detailed spectroscopic analysis and derivatization.