Psammaplysenes C and D, Cytotoxic Alkaloids from Psammoclemma sp.

Journal of Natural Products
2007.0

Abstract

The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X 7 receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X 7-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.

DOI： 10.1021/NP0703646

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