Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus <i>Brasilomena</i>, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (<b>1</b>) and 11-hydroxytolypodiol (<b>2</b>) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only <b>2</b> reduced <i>in vitro</i> thromboxane B<sub>2</sub> and superoxide anion (O<sub>2</sub><sup>-</sup>) generation from <i>Escherichia coli</i> lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.