A chemical study of the alkaloids of corydalis rosea

Chemistry of Natural Compounds
1972.0

Abstract

From the herb Corydalis rosea Leyeh. (rosy corydalis), family Papaveraceae introduced into the botanical garden of the All-Union Scientific-Research Institute of Medicinal Plants and collected on August 29, 1969, in the flowering phase, combined alkaloids were obtained using the dichloroethane method, from which five compounds were isolated by separation according to basicity. The strongly basic fraction yielded protopine (identified by comparison with an authentic sample). The main component of the feebly basic fraction was l-adlumidine (C₂₀H₁₉O₆N), characterized by spectral data, elemental composition, and oxidation to hydrastine and 6-formyl-2,3-methylenedioxybenzoic acid. An optically inactive dl-adlumidine (C₂₀H₁₉O₆N) was isolated from the methanolic mother solution of l-adlumidine. The fourth compound was l-adlumine (C₂₁H₂₁O₆N), identified via spectral analysis and mass spectrometry to determine substituent positions. An optically inactive dl-adlumine (C₂₁H₂₁O₆N), with spectra identical to l-adlumine, was obtained from the methanolic mother solution of l-adlumine.

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