Alkaloids ofCorydalis marschalliana

Chemistry of Natural Compounds
1993.0

Abstract

Alkaloids, mainly adlumidine, bicuculline, and bulbocapnine, have previously been isolated from Corydalis marschalliana Pers. (Fumariaceae). We investigated samples of C. marschalliana raw material collected in North Ossetia (t~l'khtovo region) during the flowering period in April 1991. Chloroform extraction yielded total alkaloids (3.11 g, 0.79% of air-dry raw material). Treating the nonphenolic fraction with alcohol gave stylopine (0.10 g) and isocorypalmine (0.10 g). The mother liquor was chromatographed on a silica gel column using benzene and benzene-ethanol mixtures, leading to the isolation of cheilanthifoline (0.08 g), adlumine (0.11 g), bulbocapnine (0.40 g), glaucine (0.50 g), corydine (0.09 g), norcorydine (0.005 g), isocorydine (0.02 g), and isoboldine (0.05 g). The alkaloids were identified by comparing their physical constants and spectral characteristics with literature data. Ten alkaloids were isolated from the investigated C. marschalliana sample, with bulbocapnine, adlumine, and corydine as the main ones. Norcorydine, glaucine, isocorypalmine, and adlumine were isolated from this species for the first time. The raw material from the new C. marschalliana population showed significant differences in alkaloid qualitative composition, indicating variability in the alkaloid composition of this species.

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