Termitomycesphins A–D, Novel Neuritogenic Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus

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2000.0

Abstract

Four novel cerebrosides, termitomycesphins A±D, were isolated from the edible Chinese mushroom Termitomyces albuminosus (Berk.) Heim. (`Jizong' in Chinese), shown to induce neuronal differentiation in rat PC12 cells. The absolute stereostructures were elucidated by spectroscopic methods and chemical derivatization. These new cerebrosides have a unique C19 hydroxylated sphingosine base with branching around the middle. Termitomycesphins A and C possessing a C16 a-hydroxy fatty acid showed a higher neuritogenic activity than did termitomycesphins B and D possessing a C18 a-hydroxy fatty acid.

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