The alkaloid fraction of the Amazonian species Telitoxicum peruvianum (Menispermaceae) was found to contain the known alkaloids norrufescine (l), lysicamine (6), and subsesseline (2) as well as the new alkaloids telitoxine (3), peruvianine (4), and telazoline (7). Structures are proposed for the new alkaloids on the basis of spectroscopic data.