Terpeptin, a novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1

Tetrahedron Letters
1997.0

Abstract

Terpelxin, a novel peptide having cell cycle inhibitory activity, was isolated from the cultured broth of Aspergillus terreus 951:-1 and its structure was elucidated by spectral analyses. Terpeptin inhibited the cell cycle progression of mouse tsFI210 cells in the G2/M phase with a minimum inhibitory concentration of 62.5 p-M.

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