Six novel marine natural products, dysidamides B (3) and C (5), three highly oxygenated sterols 9, 11, and 13, and a 1,4-dideoxyhexose 15 were isolated from the Red Sea sponge Dysidea herbarea, along with the previously known 24-methylene-5α-cholest-7-ene-3β,5,6β-triol (7), furodysinin lactone, and α-D-xylopyranose. Structures of all new compounds were determined from spectroscopic data, especially extensive 1D and 2D NMR experiments. Many interesting metabolites have been isolated from Dysidea species (1-7). Recently we have reported the isolation of a chlorinated nitrogenous metabolite, dysidamide [1], from a Dysidea sp. collected near Massawa, Ethiopia (8), a sponge which has now been fully identified as Dysidea herbarea Keller (family Dysideidae, order Dictyoceratida). An unusually diverse array of metabolites has been isolated from various specimens of D. herbarea (1,4). Herewith we wish to report several minor metabolites from the same sponge: two new dysidamides, B (3) and C (5), four polyoxygenated sterols 7, 9, 11, and 13, and a dideoxyhexose 15, which were isolated with D-xylose and furodysinin lactone (7).