Eight new alkaloids with PTP1B and α-glucosidase inhibitory activities from the medicinal mushroom Hericium erinaceus

Tetrahedron
2015.0

Abstract

Eight new alkaloids (1e8), were isolated from the solid culture of Hericium erinaceus. The structures of new metabolites were established by spectroscopic methods. The absolute configuration of 1 was determined by electronic circular dichroism (ECD) calculation. Compounds 5e8 showed inhibitory activities against both protein tyrosine phosphatase-1B (PTP1B) and a-glucosidase. In the cytotoxicity assay, compounds 1e4 showed moderate cytotoxicity against K562 cells with IC50 values in the range of 11.4e18.2 mM, and also weak cytotoxicity against doxorubicin resistant K562 cells.

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