Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

Tetrahedron Letters
2003.0

Abstract

Tetrapetalone A (I), C26H33O7N, is a novel lipoxygenase inhibitor isolated from a culture filtrate of Streptomyces sp. USF-4727 strain. Its chemical structure was determined by its spectroscopic evidence and methylation with diazomethane. The stereochemistry was investigated by the coupling constant in 1 H NMR, NOESY data and modified Mosher's method. I possessed a tetracyclic skeleton and a -rhodinosyl moiety, and this is the first report of a compound with such a tetracyclic skeleton.

DOI： 10.1016/S0040-4039(03)00007-8

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