Cyclolinopeptides B - E, new cyclic peptides from Linum usitatissimum

Tetrahedron
1999.0

Abstract

New cyclic nona and octapeptides, cyclolinopeptides B - E were isolated from the seeds of Linum usitatissimum and their structures were elucidated as cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Mso-Leu-Ile-), cyclo (-Pro-Phe-Phe-Trp-lle-Mso-Leu-Leu-), and cyclo (-Pro-Leu-Phe-Ile-Mso-Leu-Val-Phe-), respectively, by extensive 2D NMR methods and chemical degradations. Cyclolinopeptides B and E showed immunosuppressive activity.

DOI： 10.1016/S0040-4020(98)01086-2

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