A NEW IMMUNOSUPPRESSIVE CYCLIC NONAPEPTIDE, CYCLOLINOPEPTIDE B FROM LINUM USITATISSIMUM

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

A new cyclic nonapeptide, cyclolinopeptide B: cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), has been isolated from the seeds of Linum usitatissimum and its structure was elucidated by extensive 2D NMR methods and chemical degradations. Cyclolinopeptide B showed potent immunosuppressive activity comparable with that of cyclosporin A.

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