The seeds of Picralima nitida collected in Ghana afforded a new indole alkaloid, picratidine [1], whose structure was deduced as N-methylpicraline through interpretation of spectral data. Five other alkaloids, akuammine, akuammidine, akuammicine, akuammigine, and pseudoakuammigine, were also isolated. Picralima nitida (Stapf.) Th. & H. Durand (syn. Picralima klaineana, Pierre) is a West African plant belonging to the Apocynaceae family. The seeds are commonly used in the Ivory Coast, Ghana, and Nigeria as an antimalarial and antipyretic (1). A previous study showed that the plant was without an effect on avian malaria (2). The crude alkaloidal extract produced analgesia in the rat (3) and local anesthesia in the guinea pig. Several indole alkaloids have been previously isolated from the seeds of P. nitida (4-9). Among the pharmacologically active Picralima alkaloids are akuammine (10), akuammidine (11), and pseudoakuammigine (12). The purpose of the present investigation was to undertake the re-isolation of the seed alkaloids for their pharmacological evaluation. During the course of the study a new indole alkaloid, picratidine [1], was isolated. Its structure was deduced as N-methylpicraline through interpretation of spectral data. Re-isolation of akuammine, akuammidine, akuammicine, akuammigine, and pseudoakuammigine from the seeds of P. nitida was also realized.