A methanolic extract ofFicus septica leaves displayed intense antibacterial and antifungal activities. Bioactivity-guided fractionation with TLC bioautography led to the isolation of two indolizidine alkaloids, the novel ficuseptine, 4,6-bis-(4-methoxyphenyl)- 1,2,3-trihydroindolizidinium chloride, and antofine. The structure of ficuseptine was determined from mass spectrometry and extensive one and two dimensional NMR spectroscopy. Complete1H and13C NMR assignments for antofine are reported. © 1990 Pergamon Press plc.