<jats:title>Abstract</jats:title><jats:p>From solid cultures of the biologically important endophyte <jats:italic>Streptomyces</jats:italic> species LR4612, cultivated on <jats:italic>Maytenus hookeri</jats:italic>, four new and two known compounds were isolated. The new compounds were identified as (2<jats:italic>S</jats:italic>*,3<jats:italic>S</jats:italic>*)‐5‐amino‐3‐hydroxy‐5‐oxopentan‐2‐yl 3‐(formylamino)‐2‐hydroxybenzoate (<jats:bold>1</jats:bold>), <jats:italic>N</jats:italic>‐[(3<jats:italic>R</jats:italic>*,4<jats:italic>R</jats:italic>*)‐3‐amino‐3,4‐dihydro‐4‐methyl‐2,6‐dioxo‐2<jats:italic>H</jats:italic>,6<jats:italic>H</jats:italic>‐1,5‐benzodioxocin‐10‐yl]formamide (<jats:bold>2</jats:bold>), (5<jats:italic>β</jats:italic>,6<jats:italic>α</jats:italic>)‐6,11‐dihydroxyeudesmane (<jats:bold>3</jats:bold>), and 5‐(6,7‐dihydroxy‐6‐methyloctyl)furan‐2(5<jats:italic>H</jats:italic>)‐one (<jats:bold>4</jats:bold>); the known compounds were elucidated as sorbicillin (<jats:bold>5</jats:bold>) and <jats:italic>N</jats:italic>‐acetyltyramine (<jats:bold>6</jats:bold>). The structures were established by HR‐ESI‐MS and in‐depth NMR analyses.