From the chloroform extract of the root bark of Uvaria dependens the three new flavonoids dependensin, 5,7,8-trimethoxyflav-3-ene and 2-hydroxy-3,4,6-trimethoxychalcone have been isolated together with (-)-pipoxide and a mixture of sitosterol and stigmasterol. Structure elucidation was achieved by spectroscopic methods.