Desmodium styracifolium (Osb.) Merr. of the family Fabaceae is a small plant 40–80 cm in height and known in Vietnam by the name Kim tien thao. The whole plant is collected in Summer-Autumn and used as herbal medicines for urolithiasis, kidney problems, urethral infection, edematous nephritis, and hepatitis [1]. Previously isolated classes of compounds were volatile oil constituents, triterpenes, triterpenoid glycosides, flavonoids, flavonoid glycosides, and alkaloids [2–5]. The most systematic study [5] investigated the EtOH extract from the aerial parts of D. styracifolium from China, which found new isoflavanones, isoflavanone O-glycosides, and a coumaronochromone. The ethnomedicinal uses of the plant were supported by pharmacological studies on the prevention of kidney stones of polar constituents, flavonoid glycosides, triterpenoid glycosides, and polysaccharides, and the hypotensive action of an aqueous D. styracifolium extract [3, 4]. In the chemical study of the aerial parts of D. styracifolium originating in Vietnam, two isoflavanones, homoferreirin (1) and 5,7-dihydroxy-2,3,4 trimethoxyisoflavanone (2), two isoflavones, panchovillin (3) and genistein (4), six flavonoid C-glucosides, isoorientin (5), isoschaftoside (6), schaftoside (7), isovitexin (8), isoorientin 3-O-methyl ether (12), orientin (13), five flavonoid O-glucosides, genistin (9), ambonin (10), quercetin 3-O--D-glucopyranoside (14), astragalin (15), genistein 7-O--D-apiofuranosyl-(16)- O--D-glucopyranoside (16), and an amide, desmodilactone (11), were isolated. The structures of compounds 1–16 were determined by comparing their spectroscopic data (1H and 13C NMR) with literature values [5–13]. To the best of our knowledge, compounds 3, 6, 9, 10, 12–16 were reported for the first time from D. styracifolium.