Total synthesis of pyrrolizidines 223H′, 239K′, 265H′, and 267H′ found in Madagascan frogs ( Mantella ) and their affinities for nicotinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.

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