In addition to crinamine, bulbispermine, 3-O-acetyl hamayne and 6-hydroxycrinamine, three new alkaloids 8 alpha-ethoxy precriwelline, N-desmethyl 8 alpha-ethoxy pretazettine and N-desmethyl-8 beta-ethoxy pretazettine were isolated from Crinum bulbispermum. The structures of the new alkaloids were established by specroscopic techniques. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.