Three new indole alkaloids, viz. 10-methoxyaffinisine, 10-methoxycathafoline and alstonerinal, in addition to alstonerine, alstonisine, alstonal, alstophylline, vincamajine, lochnerine and cathafoline were isolated from the stem-bark extract of Alstonia macrophylla. (C) 1999 Elsevier Science Ltd. All rights reserved.