A new alkaloid, 19-hydroxyvincamajine, has been isolated from the leaves of Alstonia macrophylla. In addition to this, eight other indole alkaloids, alstonerine, alstophylline, macralstonine, anhydromacralstonine, talcarpine, vincamajine, vincorine and cabucraline, were also isolated and identified from the bark and leaves of A. macrophylla of Sri Lanka. The last five alkaloids have been isolated for the first time from this species and the 13NMR of alstonerine and alstophylline are reported. © 1987.