Benzastatins E, F, and G: New indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus

Tetrahedron
1997.0

Abstract

Three new indoline alkaloids, benzastatins E (5), F (6), and G (7), were isolated from the culture broth of Streptomyces nitrosporeus 30643 as neuronal cell protecting substances. Their structures were elucidated on the basis of spectral data. 5, 6, and 7 suppressed glutamate toxicity in N18-RE-105 cells with ECS, values of 1.7, 3.6, and 12.2 mu M, respectively. (C) 1997 Elsevier Science Ltd.

DOI： 10.1016/S0040-4020(97)00157-9

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