<jats:title>Abstract</jats:title> <jats:p>Seven alkaloids, rotundifoline, isorotundifoline, rhynchophylline, isorhynchophylline, ciliaphylline, rhynchociline and mitraciliatine have been isolated from the leaves of Mitragyna ciliata Aubr. et Pellegr. The latter three are hitherto undescribed alkaloids.