Three new bisbenzylisoquinoline alkaloids, (+ )-2'-norcocsoline 111, (+)- 12- 0-methylcocsoline-2 '-P-N-oxide 121, and(+)-cocsoline-2 '-P-N-oxide 131, were isolated fromcc polar fractions of the roots ofdnisocycla cymosa, in addition to eight known bisbenzyliscquinoline, aporphine, protoberberine, and phenanthrene alkaloids previously reported. Their structures were elucidated by spectroscopic and chemical methods.