From the root bark of Calophyllum inophyllum, a new xanthone named caloxanthone D and from the root heartwood, another new xanthone, caloxanthone E, in addition to four known xanthones [1,3,8-trihydroxy-7 methoxy-, 1,3-dihydroxy-7,8-methoxy-, 1,3,5-trihydroxy-2-methoxy- and 6-hydroxy-l,5-dimethoxy--I were isolated. The structures were determined by analysis of NMR spectral data including 2D techniques.