New Indole Alkaloids from Kopsia. Alkaloid Variation in Kopsia singapurensis

Helvetica Chimica Acta
2008.0

Abstract

<jats:title>Abstract</jats:title><jats:p>Five new indole alkaloids, <jats:italic>viz.</jats:italic>, kopsiloscine G (<jats:bold>2</jats:bold>), kopsidarine (<jats:bold>4</jats:bold>), kopsimaline F (<jats:bold>6</jats:bold>), kopsidine C <jats:italic>N</jats:italic>‐oxide (<jats:bold>7</jats:bold>), and aspidophylline B (<jats:bold>9</jats:bold>), in addition to 17 other known alkaloids, were obtained from the leaf and stem‐bark extract of the Malaysian <jats:italic>Kopsia singapurensis.</jats:italic> The structures were determined by using NMR and MS analysis. The results are compared with the alkaloidal composition of another sample of <jats:italic>K. singapurensis</jats:italic>, collected from the same location but at a different time of the year, as well as with other samples of <jats:italic>K. singapurensis</jats:italic> collected from different locations.

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