This investigation was inaugurated in the search for quinine substitutes on the basis that reports of the use of Garrya in the treatment of intermittent fevers have appeared in the literature. Six species of Garrya have been examined for their alkaloidal content. G. flavescens contained no alkaloids while G. fremontii and G. buxifolia yielded amorphous, basic, nitrogenous residues which did not form crystalline salts. G. elliptica, G. veatchii, and G. wrightii, on the other hand, all contained alkaloids which were isolated as crystalline hydrochlorides. Two crystalline substances have been isolated from the bark of G. veatchii and a number of their salts have been prepared. It is proposed that these substances be named Garryine and Veatchine for convenience of reference. Garryine does not give a sharp melting point but forms a hydroiodide melting at 202-203℃ (dec.). The provisional empirical formula for Garryine based on a minimal nitrogen content of one nitrogen atom is C22H32O3N(H2O). Veatchine melts at 122-123℃ and forms a hydroiodide melting at 222-223℃ (dec.). The provisional empirical formula for Veatchine based on the same assumption as above is C22H32O2N.