Ritterazines D-M (4-13) have been isolated from the tunicate Ritterella tokioka and their structures elucidated by spectral data Ritterazines D-M showed potent cytotoxicity against P388 murine leukemia cells with IC50 values of 16, 3.5, 0.73, 0.73, 16, 14, 13, 9.5, 10, and 15 ng/mL, respectively.