Isolation of 13 New Ritterazines from the Tunicate Ritterella tokioka and Chemical Transformation of Ritterazine B1

The Journal of Organic Chemistry
1997.0

Abstract

Thirteen new ritterazines, ritterazines N-Z (2-14), were isolated from the tunicate Ritterella tokioka. Chemical transformation of ritterazine B, the most active among the ritterazines, by reduction, oxidation, methanolysis, and acetylation furnished compounds 20, 21, 23, and 25-29. Cytotoxicity of 26 natural products and chemically modified ritterazine B disclosed important structural features of the ritterazines for cytotoxic activity.

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