Streptomyces sp. SUC1, endophytic on the aerial roots of Ficus benjamina was isolated and characterized on the basis of its morphology, amino acid composition of the whole-cell extract, and genomic DNA. Four novel secondary metabolites, lansai A–D, were isolated from the culture of this endophyte. The structures were identified by spectroscopic data. The compounds were tested for anticancer and antifungal activities.