Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl₂

Abstract

<i>Tetraena mongolica</i> Maxim, a relict originating from the Tertiary Period, is an endemic species of Zygophyllaceae in China. Three new monoterpenoids (<b>1</b>-<b>3</b>), two new phenols (<b>4</b>, <b>5</b>) with unusual <i>O</i>-sulfoglucosyl groups, a new flavonoid (<b>6</b>), and nine known compounds were isolated from the leaves of <i>T. mongolica</i>. The structures of these compounds were determined by interpretation of NMR, MS, and ECD data. Some of the isolated compounds showed protective effects on HEK 293t cells damaged by CdCl₂, with IC₅₀ values being 55.7 and 80.3 μM for compounds <b>7</b> and <b>8</b>, respectively, at the time point of 48 h after treatment.