<jats:title>Abstract</jats:title><jats:p>From the marine sponge <jats:italic>Ircinia variabilis</jats:italic>, three new ceramides, variceramides <jats:bold>1a</jats:bold>–<jats:bold>3a</jats:bold>, have been isolated. Their structures were deduced from spectroscopic studies and by acid hydrolysis.