The isolation and structure elucidation of a new ergot peptide alkaloid, ergobine 111, from submerged cultures of Clavictps purpurea strain 231 FI, are described. Its purification and identification were achieved by feeding experiments with a labelled precursor. The structural details have been established through chemical degradation, uv spectroscopy, hplc, amino acid analyses, 'H nmr, eims, fdms, and its isomerization to ergobinine.