A new base, neferine (methiodide, m.p. 180-182°, C38H44O6N2·2CH3I·2H2O), as well as isoliensinine, has been isolated from "Lien Tze Hsin" (embryo of Nelumbo nucifera GAERTN.) in Hong Kong market. O-Methylneferine (styphnate, m.p. 139-140°, [α]D 93.3° (acetone)) was found to be completely identical with the synthesized O, O-dimethylisoliensinine, reported previously. When O-ethylneferine was subjected to the cleavage reaction by metallic sodium in liquid ammonia, D-1, 2, 3, 4-tetrahydro-6-methoxy-1-(p-methoxybenzyl)-2-methyl-7-isoquinolinol and D-O-ethylarmepavine were obtained. Therefore, it has been verified that the structure of neferine was represented by the formula ‡V. The neferine, synthesized from ‡Y and D-3'-bromoarmepavine in the presence of cupric oxide and anhyd. potassium carbonate in pyridine was completely identical with the natural product (Table ‡T).