Flavonoids from Centaurea furfuracea (Asteraceae)

Biochemical Systematics and Ecology
2003.0

Abstract

As part of biochemical studies on the genus Centaurea, eight known flavonoids were isolated and identified from Centaurea furfuracea, namely apigenin 1, hispidulin 2, cirsimaritin 3, 5,7,4'-trihydroxy-3-methoxyflavone 4, apigenin-7-O-glucoside 5, apigenin-7-O-methylglucuronide 6, hispidulin-7-O-glucoside 7 and patelutin-7-O-glucoside 8. Dried aerial parts of C. furfuracea were extracted with 70% MeOH, partitioned with n-BuOH, and the residue was separated via polyamide column chromatography, preparative paper chromatography (Whatman 3 MM paper using 15% aqueous HOAc and BAW as solvents), and purified by Sephadex LH-20. Structures were confirmed by UV, MS, 1H NMR spectroscopy and co-chromatography with authentic samples. Chemotaxonomic analysis indicated Centaurea furfuracea is an Algerian endemic species; hispidulin-7-O-glucoside (one of the four aglycones and four glycosides isolated) is common in Algerian Centaurea species (previously found in C. incana and C. niceansis), and this species contains no C-glucosylflavonoids.

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