Recent investigations of the bryozoan Flustra foliaceae L from Scandinavian waters have revealed the presence of a series of bromoalkaloids belonging to the physostigmine group (1,2). Antibacterial testing of the CH₂Cl₂ extract from F. foliaceae collected in the Minas Basin, Nova Scotia, showed strong activity against Bacillus subtilis. Assay guided fractionation of the crude extract by open column chromatography resulted in several active fractions. Further separation of the combined fractions by thick layer chromatography and final purification by hplc yielded the bromoalkaloid dihydroflustramine C (1) as the active principle. Structure elucidation was based on spectral data (uv, hrms, cmr, pmr) and experiments (nOe, decoupling), as well as comparison with published pmr/cmr data for flustramines A-C from North Sea F. foliaceae. The physostigmine alkaloids from the Calabar bean (Physostigma venenosum Balf., Leguminosae) display potent biological activity (6), and the activity of this brominated marine analogue is currently under investigation.