The isolation and absolute configuration of (1S,2S,3R)-4- Hydroxymethylcyclopent-4-ene-1,2,3-triol: A putative intermediate in the biosynthesis of aristeromycin by Streptomyces citricolor

Tetrahedron Letters
1993.0

Abstract

The novel tetrol 5 has been isolated from cultures of Streptomyces citricolor and shown to have the absolute configuration 1S,2S,3R. Addition of 5 to an aristeromycin non-producing mutant of S. citricolor supported production of both aristeromycin 1 and neplanocin A 2, suggesting that 5 is an intermediate on the biosynthetic pathway.

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