Hypecoum imberbe, Hypecoum procumbens, and Hypecoum pendulum of Turkish origin produce the new benzophenanthridine alkaloid (*)-nitrotyrasanguinarine [1]. Until recently, the genus Hypecoum, which includes some 15 species distributed from the Mediterranean to Central Asia and Northern China, had been counted as belonging to the family Papaveraceae (1,2). It has now been recognized, however, that Hypecoum species belong more appropriately to the botanical family Hypecoaceae (1,2). This family includes only one genus and is intermediate between the Papaveraceae and the Fumariaceae (1). Protopine is known to be the main alkaloid in Hypecoum species (3). In addition, protoberberines (4), secoberbines (4), aporphines (4), spirobenzylisoquinolines (5), isoquinolones (6), and benzophenanthridines (4) are known to be present, besides the structurally uncommon (+)-turkiyenine (7). Presently, as a result of a study of Hypecoum imberbe Sibth. Sm., collected in western Turkey, we have obtained the new and unusual alkaloid (*)-nitrotyrasanguinarine [1], C₂₈H₂₂N₂O₇, which is the first isoquinoline alkaloid to incorporate an aliphatic nitro group. The occurrence of aromatic nitro groups among the isoquinoline-derived aristolochic acids is, of course, well documented (8).