<jats:title>Abstract</jats:title> <jats:p> The demosponge Pleroma menoui (order Lithistida, suborder Trienosina (= Desmophorina), family Pleromidae), collected in the Coral Sea south-east of Noum ea at a depth of 500 m, is proven here to contain the novel alkaloids ethyl 6-brom o-3-indolcarboxylate and 3-hydroxyacetyl-6-brom oindole.