Novel Bile Acids from Bear Bile Powder and Bile of Geese

Chemical and Pharmaceutical Bulletin
2009.0

Abstract

Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NMR, the structures of the new compounds were elucidated as 3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (1), 3alpha,5,7alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (2) and 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid (3).

Knowledge Graph

Similar Paper

Novel Bile Acids from Bear Bile Powder and Bile of Geese
Chemical and Pharmaceutical Bulletin 2009.0
Synthesis and Physicochemical, Biological, and Pharmacological Properties of New Bile Acids Amidated with Cyclic Amino Acids
Journal of Medicinal Chemistry 1996.0
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders
Journal of Medicinal Chemistry 2016.0
Sulfated and Nonsulfated Bile Acids in Urine of Patients with Biliary Atresia
Journal of Pediatric Gastroenterology and Nutrition 1986.0
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails
Bioorganic & Medicinal Chemistry Letters 2002.0
New<i>N</i>-Acyl Taurine from the Sea Urchin<i>Glyptocidaris crenularis</i>
Bioscience, Biotechnology, and Biochemistry 2010.0
Modification on Ursodeoxycholic Acid (UDCA) Scaffold. Discovery of Bile Acid Derivatives As Selective Agonists of Cell-Surface G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1)
Journal of Medicinal Chemistry 2014.0
Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands
Journal of Medicinal Chemistry 2014.0
Bile acid amides derived from chiral amino alcohols: novel antimicrobials and antifungals
Bioorganic &amp; Medicinal Chemistry Letters 2004.0
A radioimmunoassay for tauro‐β‐muricholic acid suitable for use with isolated rat liver cells
FEBS Letters 1983.0