Isolation and partial synthesis of 3(R)- and 3(S)-deoxypumiloside; structural revision of the key metabolite from the camptothecin producing plant, Ophiorrhiza pumila

Tetrahedron Letters
1997.0

Abstract

Both the C-3 epimeric pair of 3(R)- and 3(S)-deoxypumiloside were found in Ophiorrizia pumila (Rubiaceae), a source plant of camptothecinoid metabolites. These structures were confirmed by spectroscopic analysis and partial stereoselective syntheses. The configuration at C-3 of the previously reported 'deoxypumiloside' is revised to 3(R) from 3(S).

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