Isolation of a New Mycalolide from the Marine Sponge Mycale izuensis

Journal of Natural Products
2002.0

Abstract

Bioassay-directed fractionation of the lipophilic extract of the marine sponge Mycale izuensis led to the isolation of cytotoxic mycalolides including a new compound, 30,32-dihydroxymycalolide A (1). Its structure including absolute stereochemistry was deduced by spectroscopic and chemical methods. Compound 1 was cytotoxic against HeLa cells with an IC(50) value of 2.6 ng/mL.

Knowledge Graph

Similar Paper